locus control regions การใช้

For example, in tissues that express globin genes, the ?-globin locus control region forms a loop with these genes.
These regions have been shown to map many types of cis-regulatory elements including promoters, enhancers, insulators, silencers and locus control regions.
After this first report, locus control regions have now been identified for many genes and have permitted for example the ectopic expression of genes in transgenic mice.
The protein encoded by this gene contains a paired-like homeodomain and binds to the core of the locus control region of the red / green visual pigment gene cluster.
By using the globin gene cluster he made the ground-breaking discovery of a locus control region located upstream of the gene itself and governing overall control of globin gene expression.